于艳艳

师资介绍

姓名：于艳艳

性别：女

民族：汉族

出生年月：1988.09.22

职称：副教授

学历：博士

职务：无

研究方向：

主要研究方向DNA纳米技术在药物及体内代谢物分析中的应用。

主持或参加科研项目（课题）：

（1）    江苏省科技厅，优秀青年基金，BK20211604，基于CRISPR技术的免疫层析试纸法用于SARS-CoV-2双靶标联合检测，2021-07至2024-06，50万元，在研，主持

（2）    南京大学“生命分析化学国家重点实验室”开放基金，SKLACLS2013，变构响应型多信号三维DNA探针的构建及应用，2020-04至2022-03，5万元，已结题，主持

（3）    南通市科技局，社会民生面上，MS12021051，CRISPR多通道响应新技术的开发及用于SARS-CoV-2可视化现场检测，2021-07至2023-06，10万元，已结题，主持

（4）    南通市科技局，新型冠状病毒专项，XG202008-4，等温扩增式3D折纸芯片的研发及用于新型冠状病毒检测，2020-03至2022-02，4万元，已结题，主持

（5）    国家自然科学基金委员会，青年项目，21705082，纸基变构响应型三维传感界面的构建及其p53/MDM2相互作用抑制剂研究应用，2018-01至2020-12，25万元，已结题，主持

（6）    江苏省科技厅，青年项目，BK20170444，3D折纸芯片传感系统的构建及用于p53/MDM2相互作用抑制剂的研究，2017-07至2020-06，20万元，已结题，主持

（7）    中国博士后科学基金会，面上项目，2017M611640，集成式双信号响应型三维纳米探针的构建及传感应用，2017-01至2018-11，5万元，已结题，主持

（8）    南通市科技局，科技计划项目，MS12016023，基于DNA等温指数扩增的生物传感器用于卵巢癌的早期联合诊断，2016-10至2018-09，3万元，已结题，主持

代表性第一作者和通讯作者论文

（1）       Yuliang Kang^#, Jiali Wang^#, Wensi Zhang, Yuhang Xu, Bohui Xu, Guangbo Qu, Yanyan Yu*, Bing Yan*, Gaoxing Su*，RNA extraction-free workflow integrated with a single-tube CRISPR-Cas-based colorimetric assay for rapid SARS-CoV-2 detection in different environmental matrices，Journal of Hazardous Materials, 2023, 454，131487，通讯，IF: 13.6

（2）       Mengting Xu^#, Yuedong Zhu^#, Yan Zhang, Bin Gong, Yuliang Kang, Gaoxing Su *，Yanyan Yu*，Split G-quadruplex-programmed label-free CRISPR-Cas12a sensing system，Chemical Communications，2023, 59, 7615-7618，通讯，IF: 4.9

（3）       Yuliang Kang, Gaoxing Su*，Yanyan Yu*，Jiajia Cao, Jiali Wang, Bing Yan*，CRISPR-Cas12a-Based Aptasensor for On-Site and Highly Sensitive Detection of Microcystin-LR in Freshwater，Environmental Science & Technology，2022, 56, 4101−4110，通讯，IF: 11.4

（4）       JialongWu, Yanyan Yu* and Gaoxing Su*，Safety Assessment of 2D MXenes: In Vitro and In Vivo，Nanomaterials，2022, 12, 828，通讯，IF: 5.3

（5）       Gaoxing Su^#, Min Zhu^#, Diyuan Li, Mengting Xu, Yuedong Zhu, Yan Zhang, Hongyan Zhu, Feng Li*, Yanyan Yu*，Multiplexed lateral flow assay integrated with orthogonal CRISPR-Cas system for SARS-CoV-2 detection，Sensors and Actuators: B. Chemical，2022，371，132537，通讯，IF: 8.4

（6）       Min Zhu^#, Jianbin Pan^#, Mengting Xu, Jiajia Cao, Yuedong Zhu, Hongyan Zhu, Gaoxing Su*, Yanyan Yu*，P53-MDM2 interaction monitoring and inhibitors potency evaluation based on CRISPR-Cas12a sensing platform，Sensors and Actuators: B. Chemical，2022，361，131710，通讯，IF: 8.4

（7）       Wei S. Zhang^#，Jianbin Pan^#, Feng Li, Min Zhu, Mengting Xu, Hongyan Zhu, Yanyan Yu*, Gaoxing Su*, Reverse-Transcription Recombinase Polymerase Amplification Coupled CRISPR-Cas12a for Facile and Highly Sensitive Colorimetric SARS-CoV-2 Detection, Analytical Chemistry, 2021, 93 (8): 4126–41333，通讯，IF:7.4

（8）       Yanyan Yu^#, Wei S. Zhang^#, Yuehua Guo, Huaping Peng, Min Zhu, Dandan Miao, Gaoxing Su*, Engineering of exosome-triggered enzyme-powered DNA motors for highly sensitive fluorescence detection of tumor-derived exosomes, Biosensors and Bioelectronics, 2020, 167: 112482，一作，IF：12.6

（9）       Yanyan Yu^#, Zhongnan Huang^#, Yao Zhou, Lihua Zhang, Ailin Liu, Wei Chen*, Jianhua Lin*, Huaping Peng*, Facile and highly sensitive photoelectrochemical biosensing platform based on hierarchical architectured polydopamine/tungsten oxide nanocomposite film, Biosensors and Bioelectronics, 2019, 126: 1-6，一作，IF：12.6

（10）   Gaoxing Su^#, Min Zhu^#, Mengting Xu, Jianbin Pan, Yao Zhou, Hongyu Zhou, Wei S. Zhang, Yanli Tong*, Yanyan Yu*, Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing, Chemical Communications, 2020, 56 (88): 13583-13586，通讯，IF: 4.9

（11）   Min Zhu, Yanyan Yu*, Junfeng Zhu, Yao Zhou, Gaoxing Su, Hongyan Zhu, Yong Chen, Mingkai Liu*, Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres, Chemical Communications, 2020, 56 (61): 8599-8602，通讯，IF: 4.9

（12）   Dandan Miao, Yanyan Yu*, Yong Chen, Yin Liu, Gaoxing Su*, Facile Construction of i-Motif DNA-Conjugated Gold Nanostars as Near-Infrared and pH Dual-Responsive Targeted Drug Delivery Systems for Combined Cancer Therapy, Molecular Pharmaceutics, 2020, 17 (4): 1127-1138，通讯，IF: 4.9

（13）   Yanyan Yu, Yao Zhou, Min Zhu, Gaoxing Su*, Haohua Deng, Wei Chen*, Huaping Peng*, Dynamic split G-quadruplex programmed reversible nanodevice, Chemical Communications, 2019, 55 (3): 389-392，一作，IF: 4.9

（14）   Yanyan Yu, Yao Zhou, Min Zhu, Mingkai Liu, Hongyan Zhu, Yong Chen, Gaoxing Su*, Wei Chen*, Huaping Peng*, Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells, Chemical Communications, 2019, 55 (35): 5131-5134，一作，IF: 4.9

（15）   Yanyan Yu^#, Min Zhou^#, Wei Zhang, Lei Huang, Dandan Miao, Hongyan Zhu*, Gaoxing Su*, Rattle-Type Gold Nanorods/Porous-SiO2 Nanocomposites as Near-Infrared Light-Activated Drug Delivery Systems for Cancer Combined Chemo–Photothermal Therapy, Molecular Pharmaceutics, 2019, 16 (5): 1929-1938，一作，IF: 4.9

（16）   Yu Yanyan, Su Gaoxing, Zhu Hongyan, Zhu Qing, Chen Yong, Xu Bohui, Li Yuqin, Zhang Wei*. Proximity hybridization-mediated isothermal exponential amplification for ultrasensitive electrochemical protein detection, International Journal of Nanomedicine, 2017, 12: 5903-5914，一作，IF: 6.4

（17）   Yanyan Yu, Zuanguang Chen^*, Wensi Jian, Duanping Sun, Beibei Zhang, Xinchun Li, Meicun Yao^*, Ultrasensitive electrochemical detection of avian influenza A (H7N9) virus DNA based on isothermal exponential amplification coupled with hybridization chain reaction of DNAzyme nanowires, Biosensors and Bioelectronics, 2015, 64: 566-571，一作，IF: 12.6

（18）   Yanyan Yu, Zuanguang Chen^*, Lijuan Shi, Fan Yang, Jianbin Pan, Beibei Zhang, Duanping Sun, Ultrasensitive Electrochemical Detection of MicroRNA Based on an Arched Probe Mediated Isothermal Exponential Amplification, Analytical Chemistry, 2014, 86 (16): 8200-8205，一作，IF: 7.4

（19）   Yanyan Yu, Zuanguang Chen, Sijing He, Beibei Zhang, Xinchun Li, Meicun Yao^*, Direct electron transfer of glucose oxidase and biosensing for glucose based on PDDA-capped gold nanoparticle modified graphene/multi-walled carbon nanotubes electrode, Biosensors and Bioelectronics, 2014, 52: 147-152，一作，IF: 12.6

（20）   Yanyan Yu, Zuanguang Chen^*, Beibei Zhang, Xinchun Li, Jianbin Pan, Selective and sensitive determination of uric acid in the presence of ascorbic acid and dopamine by PDDA functionalized graphene/graphite composite electrode, Talanta, 2013, 112: 31-36，一作，IF: 6.1