朱清
师资介绍
姓名：朱清
性别：男
出生年月：1978.08
学历：医学博士
职称：教授；博士生导师（特种医学研究院）
职务：天然药物与药物分析系主任
邮箱：zhuqing@ntu.edu.cn
研究方向：
天然镇痛药物研发；药物动力学以及代谢组学研究
学术兼职：
Frontiers in Pharmacology评审编辑
教育部学位中心硕士研究生论文盲审专家
多种SCI杂志审稿人
科研项目：
1. 国家自然科学基金面上项目，82071238，基于疼痛抑制行为探讨去甲青藤碱靶向α2-GABAA受体的镇痛效应，2021/01-2024/12，55万，在研，主持（PI）
2. 江苏省自然科学基金面上项目，BK20181459，基于疼痛抑制行为的去甲青藤碱镇痛效应及与GABAA受体相关机制研究，2018/07-2021/06，10万，结题，主持（PI）
3. 江苏省自然科学青年基金项目，BK20181459，益母草碱抗心肌缺血作用及药效物质基础的代谢组学研究，2013/07-2016/06，20万，结题，主持（PI）
4. 国家自然科学基金面上项目，81971243，TAAR1-CaMKII-CREB信号通路调节尼古丁成瘾，2020/01-2023/12，55万，在研，副主持（Co-PI）
5. 国家自然科学基金面上项目，81373390，选择性咪唑啉I2受体配体的镇痛效应及滥用潜力研究，2014/01-2017/12，65万元，结题，副主持（Co-PI）
6. 中国博士后自然科学基金面上项目，2016M591898, 基于疼痛抑制行为的青藤碱及其代谢物镇痛作用研究，2016/05-2019/05，5万元，结题，主持（PI）
代表性论文：
1. Lulu Yu, Xunjia Qian, Yiheng Feng, Yujian Yin, Xiao-Dan Zhang, Qianqian Wei, Liyun Wang, Weiwei Rong, Jie-Jia Li, Jun-Xu Li*, Qing Zhu*. Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method. Front Chem. 2023, 11:1222560. doi: 10.3389/fchem.2023.1222560. （通讯作者）
2. Huixiao Duo*, Jiayuan Yue, Yujian Yin, Xiaoyu Xu, Liyun Wang, Lulu Yu, Xunjia Qian, Jiejia Li, Qing Zhu*.Magnetic carbon nanoparticles derived from Co-based metal-organic frameworks for magnetic solid-phase extraction and determination of phenylurea herbicides. Microchem. J., 2023, 185:108190.（通讯作者）
3. Weiwei Rong, Jiejia Li, Dingyi Pan, Qinbei Zhou, Yexuan Zhang, Qianxing Lu, Liyun Wang, Andong Wang, Yizhun Zhu*, Qing Zhu*. Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver–Cardiac Crosstalk Metabolomics Study. Biomolecules, 2022, 12, 1512. （通讯作者）
4. Feifeng Yang, Yue Zhu, Congyu Zhang, Ziyan Yang, Jia Yuan, Qing Zhu*, Shushu Ding*. A highly sensitive and selective artificial nanochannel for in situ detection of hydroxyl radicals in single living cell. Anal. Chim. Acta., 2022 1235:340537（通讯作者）
5. Weiwei Rong, Jiejia Li, Lifeng Wang, Shanshan Luo, Tulu Liang, Xunjia Qian, Xiaodan Zhang, Qinbei Zhou, Yizhun Zhu*, Qing Zhu*. Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy. Front. Cardiovasc. Med., 2022, 9: 969553.（通讯作者）
6. Ming-Cong Zheng, Wen-Ting Tang, Lu-Lu Yu, Xun-Jia Qian, Jie Ren, Jie-Jia Li, Wei-Wei Rong, Jun-Xu Li and Qing Zhu*. Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration. Molecules, 2022, 27, 3570.（通讯作者）
7. Xiaohua Pan#, Qing Zhu#, Li-Long Pan*, Jia Sun*. Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy. Pharmacol. & Ther., 2022，238: 108176. （共同第一作者）
8. Zhiyong Zhou, Nanqing Qiu, Yuntao Ou, QianqianWei, WentingTang, Mingcong Zheng, Yaluan Xing, Jie‑Jia Li, Yong Ling, Junxu Li* & Qing Zhu*. N‑Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and infammatory pain in mice. Sci. Rep., 2021, 11:9300. （通讯作者）
9. Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li*, Qing Zhu*. Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. Eur. J. Pharmacol. 2018, 823:105–109. （通讯作者）
10. Yong Ling, Jing Guo, Qiuxing Yang, Peng Zhu, Jiefei Miao, Weijie Gao, Yanfu Peng, Jiaying Yang, Kun Xu, Biao Xiong, Gongqing Liu, Jinhua Tao, Lin Luo, Qing Zhu*, Yanan Zhang*. Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells. Eur. J. Med. Chem., 2018, 144:398-409. （通讯作者）
11. Qing Zhu, Yuehua Sun, Lina Mao, Chengpeng Liu, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of postoperative pain，Brit. J. Pharmacol., 2016, 173:1693-1702.
12. Qing Zhu, Li-Na Mao, Cheng-Peng Liu, Yue-Hua Sun, Bo Jiang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of vitexin in a mouse model of postoperative pain. Sci. Rep., 2016, 6:19266.
13. Qing Zhu, Yuehua Sun, Jie Zhu, Tian Fang, Wei Zhang & Jun-Xu Li. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Sci. Rep., 2014, 4: 7270.
14. Qing Zhu, Yuehua Sun, Xiaodi Yun, Yuntao Ou, Wei Zhang & Jun-Xu Li. Antinociceptive effects of curcumin in a rat model of postoperative pain, Sci. Rep., 2014, 4:4932.
15. Qing Zhu, Jinlian Zhang, Ping Yang, Bo Tan, Xinhua Liu, Yuanting Zheng, Weimin Cai & Yizhun Zhu. Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry, Sci. World J., 2014, 2014:947946.
16. Qing Zhu, Weimin Cai, Xianyi Sha, Guo Ma, Yuanting Zheng, Xueru Shi & Yizhun Zhu. Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats, Biomed. Chromatogr., 2012, 26(4): 518-523.
17. Jie-Jia Li#, Qing Zhu#, Ya-Peng Lu, Peng Zhao, Zhan-Bo Feng, Zhong-Ming Qian & Li Zhu. Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain, Brain Res., 2015,1595:19-28. （共同第一作者）
18. Donggeng Wang#, Qing Zhu #, Baohua Liu, Guangtong Chen & Yong Ling. Identification of gut microbial metabolites of a synthetic nitric oxide-releasing farnesylthiosalicylic acid derivative, an antitumor agent, Anal. Lett., 2014, 47(2):191-201.（共同第一作者）
19. Qing Zhu, Jinhua Gu, Hongyan Zhu & Jiliang Xu. Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats, Neurosci. Bull., 2008, 24(4):219-24.
授权发明专利
1. Zhu, Qing, et al. anlagesic drug composition. 2020/12/18, Nigeria，NG/PT/C/2020/4763.
2. 朱清，李俊旭，苏漫，李洁佳，欧云淘，一种镇痛药物组合物，2021/03/19
中国，ZL201710671939.4
3. 朱清，卫蒨蒨，唐文婷，李俊旭，潘菲，邱男青，周致用，李洁佳，氧化前胡素的新用途，2020/05/08，中国ZL201810813028.5
4. 朱清，李俊旭，卫蒨蒨，潘菲，邱男青，李洁佳，氧化前胡素在制备治疗术后疼痛药物中的应用，2020/04/28，中国ZL201810751676.2
5. 朱清，李俊旭，孙越华，青藤碱在制备治疗慢性疼痛伴抑郁行为药物中的应用，2017/01/04，中国，ZL201410456667.2
6. 李俊旭，朱清，欧云淘，苏漫，赵颖，去甲青藤碱在制备镇痛药物中的应用，2019/12/20 中国，ZL201610331233.9
7. 李俊旭，朱清，毛丽娜，刘成鹏，孙越华，牡荆素在制备治疗术后疼痛中的应用，2017.11.07，中国，ZL201510642790.8
获奖情况：
2023年荣获南通市药学会优秀学术带头人奖；
2022年yl6809永利官网“互联网+”大学生创业大赛二等奖（指导教师）
2015年获南通市科学技术进步奖二等奖（排名第四）；
2011年获yl6809永利官网2011届毕业设计（论文）优秀指导教师