张小玲
师资介绍
张小玲，女，汉族，1989年12月，副教授，硕士生导师。
研究方向：
抗帕金森病中药有效成分及分子机制研究
社会学术兼职：
中国民族医药学会会员
中国民族医药学会药理与毒理学分会理事
人才称号：
江苏省高层次创新创业人才引进计划资助项目-江苏省双创博士人才项目
基金项目：
1.国家自然科学基金青年项目：基于CacyBP/SIP介导的α-synuclein自噬降解调控探讨虫草素对帕金森病早期嗅觉障碍的干预及其机制研究（2022/01-2024/12, 30万元，8210141560），在研，张小玲，负责人。
2.江苏省自然科学基金青年项目。知母宁基于SBP1/GPX1通路在肝纤维化上皮细胞-间充质转化中的作用及机制研究（2019/06-2022/06，20万元，BK20190909），已结题，张小玲，负责人。
3.中国博士后科学基金，基于SBP1介导上皮细胞-间充质转化探讨刺芒柄花素抗肝纤维化作用及机制研究(2022/9-2025/8，8万，No.2022M721726)，在研，张小玲，负责人。
4.天然药物活性物质与功能国家重点实验室项目：壮药鸡血藤活性成分刺芒柄花素靶向SBP1介导EMT抗肝纤维化作用及机制研究（2020.1-2021.12，9万，GTZK202008），在研，张小玲，负责人。
科研成果：
代表性论文
1. Ming-Xuan Liu, * Li Xu, Yu-Ting Cai, Ruo-Jia Wang, Ying-Ying Gu, Yan-Chao Liu, Yu-Jin Zou, Yong-Mei Zhao, Jing Chen,* Xiao-Ling Zhang*, Carbon Nitride‐Based siRNA Vectors with Self‐Produced O2 Effects for Targeting Combination Therapy of Liver Fibrosis via HIF‐1α‐mediated TGF‐β1/Smad Pathway. Advanced Healthcare Materials, 2023, 2301485. (IF: 10.0)
2. Yingying Gu, Jiaying Zhang, Xinru Zhao, Wenyuan Nie, Xiaole Xu, Mingxuan Liu*, Xiaoling Zhang*, Olfactory dysfunction and its related molecular mechanisms in Parkinson’s disease. Neural Regeneration Research, 2024, 19, 583-590. (IF: 6.1)
3. Ming-Xuan Liu*, LiXu, Jia-Yi Jiang, Hai-Chen Dong, Peng-Fei Zhu, Lei Cao, Jing Chen*, Xiao-Ling Zhang*, Light controlled self-escape capability of non-cationic carbon nitride-based nanosheets in lysosomes for hepatocellular carcinoma targeting stimulus-responsive gene delivery. Bioengineering & Translational Medicine, 2023, e10558. (IF: 7.2)
4. Ming-Xuan Liu, Li Xu, Peng-Fei Zhu, Xin Li, Miao Shan, Wei Jin, Jing Chen*, Yong Ling*, Xiao-Ling Zhang*, Two-photon excited red-green discoloration bioprobes for monitoring lipid droplets and lipid droplet-lysosomal autophagy, Journal of Materials Chemistry B, 2023, 11, 3186-3194. (IF: 7.0)
5. Xiaoling Zhang*, Xiaoyan Zhang, Xiaoqun Ge, et al. Mangiferin prevents hepatocyte epithelial-mesenchymal transition in liver fibrosis via targeting HSP27-mediated JAK2/STAT3 and TGF-β1/Smad pathway. Phytotherapy Research, 2022,36(11):4167-4182. (IF:7.2)
10 Xiaoling Zhang*, Xiaoyan Zhang, Wenmin Huang, et al. The role of heat shock proteins in the regulation of fibrotic diseases. Biomedicine & Pharmacotherapy. 135 (2021) 111067(IF:7.419)
11 Ying Sun, Wenmin Huang, Peichen Tang, Xin Zhang, Xiaoyan Zhang, Bocheng Yu, YiYun Fan, Xiaoqun Ge*, Xiaoling Zhang**. Neuroprotective effects of natural cordycepin on LPS-induced Parkinson’s disease through suppressing TLR4/NF-κB/NLRP3-mediated pyroptosis. Journal of Functional Foods. 2020，75: 104274 (IF: 4.451)
12 Xiaoling Zhang, Wenmin Huang, Ying Sun, et al. Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission.Neurotoxicology.2021, 84: 1-13. (IF:4.294).
13 Xiaoling Zhang, Wenmin Huanga, Qianhang Shao, et al. Drp1, a potential therapeutic target for Parkinson's disease, is involved in olfactory bulb pathological alteration in the Rotenone-induced rat model. Toxicology Letters.2020, 325, 1-13. (IF: 4.372).
14 Xiaoling Zhang, Wenmin Huanga, Yiyun Fan, et al. Role of GTPases in the regulation of mitochondrial dynamics in Parkinson's disease.Experimental Cell Research. 2019,382: 111460. (IF: 3.3).
15 Xiaoling Zhang, Zhenzhen Wang,Qianhang Shao, et al.RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells. Brain research bulletin. 2019, 146:228-236. (IF: 3.44).
16 Xiaoling Zhang, Yuhe Yuan,Qianhang Shao, et al. DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult.Toxicology Letters,2017, 271:74-83. (IF: 3.858).
17 Xiaoling Zhang, Lina Xu, Lianhong Yin, et al. Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats. Chemical Communications, 2015, 51 (55): 11604-11607. (IF: 6.567).
18 Xiaoling Zhang, Xu Han, Lianhong Yin, et al. Potent effects of dioscin against liver fibrosis. Scientific Reports, 2015, 5: 9713. (IF: 5.228).
19 Xiaoling Zhang, Youwei Xu, Yan Qi, et al. Potent effects of dioscin against thioacetamide-induced liver fibrosis through attenuating oxidative stress in turn inhibiting inflammation, TGF-β/Smad and MAPK signaling pathways. Journal of Functional Foods, 2015, 16: 436-447. (IF: 3.973).