陈婷婷
师资介绍
姓名:陈婷婷
性别:女
民族:汉
出生年月:1989年5月1日
职称:副教授
学历:博士
职务:无
研究方向:神经药理
基金项目:
1.国家自然科学基金,青年基金,81901098,抑制Ras法尼基化改善阿尔兹海默病认知功能的分子机制研究,2020–01至2022–12,20.50万,在研,主持。
2.江苏省自然科学基金,青年基金,BK20190923,抑制Ras 法尼基化抗痴呆的神经保护作用机制研究,2019–07至2022–6,20万,在研,主持。
3.市科学计划项目,JC2018009,小G 蛋白Ras 活性抑制对阿尔兹海默病认知功能的调控机制,2018–07至2020–06,5万,结题,主持
科研成果:
代表性论文:
(1)Cai C, Wang L, Li S, Lou S, Luo J, Fu D, Chen T*(通讯作者). Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ 1-42 Mice via α7nAChR-Dependent BDNF Upregulation. J Neurosci. 2022 Aug 3;42(31):6090-6107. (一区)
(2)Yang C, Ni H, Yin J, Zhou T, Gu Q, Chen T*, Cai C*(共同通讯作者). Atorvastatin ameliorates depressive behaviors via regulation of α7nAChR expression by PI3K/Akt-BDNF pathway in mice. Biochem Biophys Res Commun. 2022 Feb 19;593:57-64. PMID: 35063770. (三区)
(3)Wee Meng Lim, Eunice W M Chin, Bor Luen Tang, Tingting Chen*, Eyleen L K Goh*(共同通讯作者). WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons. Front Mol Neurosci. 2021 Nov 10;14:762142. (二区)
(4)Chen Tingting*; Cai Chengyun; Wang Lifeng; Li Shixin; Chen Ling *(第一作者兼通讯作者); Farnesy Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking, Frontiers in Pharmacology, 2020, 11. (二区)
(5)Chen Tingting#; Wang Ya#; Zhang Tingting; Zhang Baofeng; Chen Lei; Zhao Liandong; Chen Ling*(第一作者); Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways, Frontiers in Pharmacology, 2018, 9: 362. (二区)
(6)Chen Tingting; Tanaka Motoki; Wang Ya; Sha Sha; Furuya Kishio; Chen Ling*; Sokabe M*(第一作者); Neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic GLT-1 via σ1 receptor-mediated PKC activation in the hippocampal dentate gyrus of rats, Glia, 2017, 65: 1491-1503. (二区)
(7)Chen Tingting; Wang Conghui; Sha Sha; Zhou Libin; Chen Lei*; Chen Ling*(第一作者); Simvastatin Enhances Spatial Memory and Long-Term Potentiation in Hippocampal CA1 via Upregulation of α7Nicotinic Acetylcholine Receptor, Molecular Neurobiology, 2016, 53: 4060-4072. (二区)
(8)Chen Tingting; Zhang Baofeng; Li Guoxi; Chen Lei; Chen Ling*(第一作者); Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons, Neuropharmacology, 2016, 107: 411-421. (二区)