王开开

师资介绍

性别：男       

出生年月：1985.12      

民族：汉          

职称：副教授

学历：博士研究生

研究方向：药物递送系统

基金项目：

中国博士后基金面上项目，2016M601923、具有靶向和促释双功能纳米递药系统的研究、2016/11-2018/6、5万元、结题，主持。

江苏省高等学校自然科学基金，深层次递氧氟化纳米粒用于肿瘤的光动力免疫协同治疗、2019/9-2021.8、5万，主持

国家自然科学青年基金，多级可控深层次递氧纳米制剂用于肿瘤的光动力免疫协同治疗、2020/1-2022/12、20万，主持

2020年江苏省双创博士， 15万，主持

科研成果：

基于生物材料为载体的纳米药物基础研究。高等学校科学研究成果奖（科学技术）教育部一等奖，排名第九

代表性论文：

1, Wang, K, Chen, G, Q. Hu, Y. Zhen, H. Li, J. Chen, B. Di, Y. Hu, M. Sun, D. Oupicky. Self-assembled hemoglobin nanoparticles for improved oral photosensitizer delivery and photothermal therapy in vivo. Nanomedicine, 2017, 12 (9) :1043-1055.

2. Huan, X., Chen, Y., Wu, X., Wang, H., Yang, Y., Wu, P., Liu, T., Wang, K*. and Ding, D*. (2023), Balancing and Therapeutic Roles of CXCR4-inhibiting Nanomedicine via Synergetic Regulation of Hepatic Stellate Cells and Extracellular Matrix in Liver injury. Chin. J. Chem.. Accepted Author Manuscript. https://doi.org/10.1002/cjoc.202300217

3. Gong G, Qian W, Zhang L, Jia J, Xie J, Zhu Q, Liu W, Tu P, Gao M, Zhang L, Tang H, Su H, Wei K*, Zhou C*, Wang K*, Pan Q*. A curcumin-induced assembly of a transferrin nanocarrier system and its antitumor effect. Colloids Surf B Biointerfaces. 2022 Sep;217:112613.

4. Fu Z, Wang X, Lu X, Yang Y, Zhao L, Zhou L, Wang K*, Fu H*. Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy. Front Bioeng Biotechnol. 2022 Aug 15;10:962380.

5. Yin, S.; Song, J.; Liu, D.; Wang, K.*; Qi, J*. NIR-II AIEgens with Photodynamic Effect for Advanced Theranostics. Molecules 2022, 27, 6649.

6, Chen, G, Wang, K,* (共一及共同通讯作者), Zhou, Y., Ding, L., Ullah, A., Hu, Q., Sun, M* & Oupický, D*. (2016). Oral Nanostructured Lipid Carriers Loaded with Near-Infrared Dye for Image-Guided Photothermal Therapy. ACS Applied Materials & Interfaces, 8(38), 25087-25095.

7. Chen, G., Zhao, Y., Xu, Y., Zhu, C., Liu, T*., & Wang, K*. (2020). Chitosan nanoparticles for oral photothermally enhanced photodynamic therapy of colon cancer. International Journal of Pharmaceutics, 589, 119763.

8. Wu, P., Yin, S., Liu, T., Ding, D*., & Wang, K*. (2021). “Building-block crosslinking” micelles for enhancing cellular transfection of biocompatible polycations. Science China Materials, 64(1), 241-251.

9. Wu, P^#, Jiang, X^#, Yin, S, Yang, Y, Liu, T, Wang, K*. (2021) Biomimetic recombinant of red blood cell membranes for improved photothermal therapy [J]. Journal of Nanobiotechnology

10. Zhao, Y., Chen, G., Meng, Z., Gong, G., Zhao, W., Wang, K.*, & Liu, T. (2019). A novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy. Drug Delivery, 26(1), 717-723.